* For illustration purpose only
Prednisone (frequent) is a hormonal drug, and it is glucocorticoid.
Prednisone (established) is a synthetic glucocorticoid, a dehydrated analog of hydrocortisone. It has anti-inflammatory, anti-allergic, desensitizing, anti-surprise, anti-toxic and immunosuppressive, anti-pruritic and anti-exudative impact.
Interacting with particular cytoplasmic receptors, Prednisone (widespread) bureaucracy a complicated that penetrates into the cell nucleus, stimulates the synthesis RNA (ribonucleic acid), inducing biosynthesis of proteins (together with lipocortin).
Pharmacological movement of the Prednisone (ordinary) for systemic use (pills, injection answer in ampoules Prednisolone):
Protein metabolism: reduces the content of globulins in the plasma, increasing synthesis in the liver and kidney albumin (with an growth in the ratio of albumin/globulin);
will increase protein catabolism in muscles;
Lipid metabolism: stimulates the synthesis of triglycerides and higher fatty acids;
Redistributes fat deposits, shifting them mainly within the place of the face, shoulder girdle, abdomen;
might also lead to the improvement of hypercholesterolemia;
Carbohydrate metabolism: enhances the absorption of carbohydrates from the digestive tract (gastrointestinal tract);
increases the glide of glucose from the liver because of the growth of glucose-6-phosphatase pastime;
increases the pastime of PEPC (phosphoenolpyruvate carboxykinase) and improves the synthesis of aminotransferases via activating gluconeogenesis;
may cause the development of hyperglycemia;
Water and electrolyte balance: keeps sodium and water inside the frame;
Stimulates potassium excretion because of an increase in mineralocorticoid activity;
Prednisone (typical), while used as an ointment, has anti inflammatory, anti-allergic, antipruritic and anti-exudative outcomes. additionally, it inhibits the formation of arachidonic acid, the formation and launch of inflammatory mediators (prostaglandins, histamine, lysosomal enzymes, leukotrienes, and so on.)
Prednisone (commonplace) suppresses inflammatory skin reactions, reduces vasodilation and accelerated vascular permeability within the inflammatory awareness.
Medically reviewed by Dr. Josette Davignon
Last updated: 22.06.2022